CHILL-ART
(2026)Objective
To test whether catheter-based intra-arterial focal hypothermia adjunct to EVT improves 90-day functional outcome in anterior circulation LVO stroke.
Study Summary
• Primary 90-day mRS 0-2: 54.7% vs 39.8% (P=0.018), NNT=7.
• 90d mRS shift aOR 1.72 (1.12-2.05).
• sICH 7.0% vs 9.0% (NS); any ICH 21.7% vs 29.3% (NS).
• Sham control had lower-than-expected good-outcome rate (room-temp vs body-temp).
• 90d mRS shift aOR 1.72 (1.12-2.05).
• sICH 7.0% vs 9.0% (NS); any ICH 21.7% vs 29.3% (NS).
• Sham control had lower-than-expected good-outcome rate (room-temp vs body-temp).
Intervention
IA cold saline (4 degC) via microcatheter + EVT vs IA room-temperature saline + EVT (sham)
Inclusion Criteria
China, n=262. ICA-IC or M1 occlusion, NIHSS >=6, EVT within 24 h.
Study Design
Arms: IA hypothermia + EVT vs sham (room-temp saline) + EVT
Patients per Arm: Hypothermia n=129 vs Sham n=133 (total 262)
Outcome
• Primary 90-day mRS 0-2: 54.7% vs 39.8% (P=0.018), NNT=7.
• 90d mRS shift: aOR 1.72 (1.12-2.05).
• sICH: 7.0% vs 9.0% (NS).
• Any ICH: 21.7% vs 29.3% (NS).
• No increase in mortality or related complications.
• 90d mRS shift: aOR 1.72 (1.12-2.05).
• sICH: 7.0% vs 9.0% (NS).
• Any ICH: 21.7% vs 29.3% (NS).
• No increase in mortality or related complications.