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HINTS

H.I.N.T.S. to Diagnose Stroke in the Acute Vestibular Syndrome — Three-Step Bedside Oculomotor Exam More Sensitive than Early MRI DWI

Year of Publication: 2009

Authors: Newman-Toker DE, Kattah JC, Talkad AV, ..., Hsieh YH

Journal: Stroke

Citation: Newman-Toker DE, et al. Stroke. 2009;40(11):3504-3510.

Link: https://doi.org/10.1161/STROKEAHA.109.551234


Clinical Question

In patients presenting with acute vestibular syndrome and at least one stroke risk factor, can a three-step bedside oculomotor examination (HINTS) differentiate posterior circulation stroke from acute peripheral vestibulopathy more accurately than initial MRI with DWI?

Bottom Line

The HINTS exam (Head-Impulse-Nystagmus-Test-of-Skew) was 100% sensitive and 96% specific for identifying stroke in acute vestibular syndrome, outperforming initial MRI DWI which was only 88% sensitive. A benign HINTS result at the bedside rules out stroke better than a negative MRI with DWI in the first 24-48 hours after symptom onset. This simple 1-minute exam should be incorporated into the evaluation of all patients presenting with acute vertigo and stroke risk factors.

Major Points

  • 101 consecutive high-risk AVS patients enrolled: 25 peripheral (vestibular neuritis) and 76 central (69 ischemic strokes, 4 hemorrhages, 3 pontine/other CNS lesions). Study population was 65% male, mean age 62 years.
  • The HINTS exam defines 'dangerous' signs as: normal h-HIT (Impulse Normal), direction-changing horizontal nystagmus (Fast-phase Alternating), or skew deviation (Refixation on Cover Test) — mnemonic: I.N.F.A.R.C.T.
  • A dangerous HINTS result was 100% sensitive and 96% specific for stroke — positive LR 25 (95% CI 3.66-170.59), negative LR 0.00 (95% CI 0.00-0.11). No strokes were missed by HINTS.
  • Initial MRI DWI was falsely negative in 8 of 69 ischemic stroke patients (12%): 5 lateral medullary, 1 lateral ponto-medullary, and 2 middle cerebellar peduncle infarctions. All false negatives occurred within the first 8-48 hours.
  • For lateral medullary and lateral pontine strokes specifically, HINTS sensitivity was 100% vs MRI DWI sensitivity of only 72% (P=0.004), with comparable specificity (96% vs 100%, P=1.0).
  • Skew deviation was present in 17% of central lesions overall and 30% of those with brainstem involvement (χ² P=0.003). It was particularly useful in identifying lateral pontine strokes where abnormal h-HIT falsely suggested peripheral disease (correctly reclassified 2 of 3 cases).
  • Lateral brainstem and inferior cerebellar strokes (n=24) most closely mimicked peripheral vestibulopathy — 45% had no obvious neurologic or oculomotor signs, compared to only 5% of medial brainstem strokes (P=0.001).
  • HINTS was more sensitive than traditional neurologic signs: general neurologic signs 19%, obvious oculomotor signs 28%, severe truncal ataxia 33%, any obvious signs combined 64% — all significantly inferior to HINTS 100% (all P<0.001).
  • The entire HINTS exam can be performed in approximately 1 minute at the bedside, compared to 5-10 minutes for traditional neurologic exam and hours for MRI with DWI.
  • 15 of 69 stroke patients (22%) were under age 50, and 6 were under age 40. Four had vertebral artery dissection — vertebral dissection is the leading cause of posterior circulation stroke in young adults.

Design

Study Type: Prospective, cross-sectional diagnostic accuracy study

Randomization:

Blinding: Examiner masked to neuroimaging results at time of clinical assessment

Enrollment Period: Approximately 1999-2008 (over 9 years)

Follow-up Duration: Until discharge with serial daily examinations

Centers: 1

Countries: United States

Sample Size: 101

Analysis: Sensitivity, specificity, likelihood ratios with 95% CI; Fisher exact and Pearson chi-squared


Inclusion Criteria

  • Acute vestibular syndrome: rapid onset (seconds to hours) of vertigo, nausea/vomiting, and gait unsteadiness with head-motion intolerance and nystagmus, lasting days to weeks.
  • At least one stroke risk factor: smoking, hypertension, diabetes, hyperlipidemia, atrial fibrillation, eclampsia, hypercoagulable state, recent cervical trauma, or prior stroke/MI.
  • Identified primarily from ED or review of cerebellar infarction admissions.

Exclusion Criteria

  • History of prior recurrent vertigo (with or without auditory symptoms) — excluded 19 patients (7 Meniere syndrome, 5 vestibular migraine, 4 idiopathic recurrent vertigo, 3 other).
  • Refusal to participate (1 eligible subject excluded).

Arms

FieldControlCentral AVS
InterventionPatients with confirmed acute peripheral vestibulopathy (vestibular neuritis) — benign HINTS expectedPatients with confirmed central lesions — dangerous HINTS expected
DurationN/A (diagnostic study)N/A (diagnostic study)

Outcomes

OutcomeTypeControlInterventionHR / OR / RRP-value
HINTS sensitivity for central lesionsPrimaryN/A (diagnostic study)100% sensitivity (76/76), 96% specificity (24/25)
MRI DWI sensitivity for ischemic strokeSecondary88% (61/69; 8 false negatives in first 24-48h)
HINTS vs MRI for lateral medullary/pontine strokesSecondaryMRI DWI 72%HINTS 100%0.004
Skew deviation in central lesionsSecondary17% overall; 30% with brainstem involvement0.003

Subgroup Analysis

Lateral brainstem/inferior cerebellar strokes mimicked APV most closely — 45% had absent general neurologic or obvious oculomotor signs vs 5% of medial brainstem strokes (P=0.001). False negative MRI: 5 lateral medullary, 1 lateral ponto-medullary, 2 middle cerebellar peduncle.


Criticisms

  • Single-center study with a single expert neuro-ophthalmologist (JCK) performing all examinations — generalizability to non-specialists is uncertain.
  • Examiner was not fully masked: although blinded to imaging, he was aware of clinical history and general neurologic exam findings, which could introduce observer bias.
  • Highly enriched cohort (76% central, 73% cerebrovascular, 69% ischemic stroke) due to enrollment requiring ≥1 stroke risk factor — may not reflect typical ED vertigo population.
  • Selective MRI follow-up: only 8 patients with initial negative MRI underwent repeat imaging, potentially missing some misclassified strokes in the APV group.
  • Small sample of peripheral cases (n=25) limits precision of specificity estimate.
  • The 96% specificity means 1 in 25 peripheral patients had a false-positive dangerous HINTS — in a lower-prevalence setting, false positives could be more problematic.
  • Does not address reproducibility of subtle oculomotor findings by non-specialists, though subsequent studies have shown reasonable inter-rater reliability.

Funding

National Institutes of Health (NIH RR17324-01) and Agency for Healthcare Research and Quality (AHRQ HS017755-01). No conflicts of interest reported.

Based on: HINTS (Stroke, 2009)

Authors: Newman-Toker DE, Kattah JC, Talkad AV, ..., Hsieh YH

Citation: Newman-Toker DE, et al. Stroke. 2009;40(11):3504-3510.

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