Epilepsy Trials

Do levetiracetam and brivaracetam differ meaningfully in their adverse event profiles compared to placebo and to each other?

Can eslicarbazepine acetate prevent the development of post-stroke epilepsy in patients at high risk after acute stroke?

Can perampanel monotherapy at 4-8 mg/day provide sustained long-term seizure freedom and acceptable tolerability in adolescent and adult patients with newly diagnosed or currently untreated recurrent focal-onset seizures?

Is intrathecal zorevunersen, an antisense oligonucleotide that upregulates NaV1.1 sodium channels, safe and effective in reducing seizures in children and adolescents with Dravet syndrome?

Does fenfluramine reduce convulsive seizure frequency in children and young adults with Dravet syndrome who have inadequate seizure control despite current antiepileptic drug therapy?

In pregnant women taking antiseizure medications as monotherapy during the first trimester, what is the risk of major congenital malformations for each specific ASM compared to lamotrigine?

Does immediate antiepileptic drug treatment after a first or early seizures improve long-term seizure outcomes compared to deferring treatment until the patient and clinician agree it is necessary?