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Oncology Trials

July 2026 · 9 Trials · NeuroTrials.ai
FEATURED ARTICLE
Can a CDK4/6 inhibitor shrink or stabilize progressive meningiomas harboring NF2 or CDK pathway mutations?

Alliance A071401

Abemaciclib in meningiomas with somatic NF2 or CDK pathway alterations: the phase 2 Alliance A071401 trial

Nature Medicine · 2026

Bottom Line: Abemaciclib met its primary PFS6 endpoint (58%) in progressive grade 2–3 meningiomas with NF2/CDK alterations. First genomically matched systemic therapy showing activity in meningiomas.

TARGETED THERAPY 1

BIOMEDE

2026

Adding biomarker-matched erlotinib, everolimus or dasatinib to radiotherapy did NOT improve overall survival in DIPG (median OS ~10–12 months across arms, no different from historical controls), but...

Nature Medicine

IMMUNOTHERAPY / ONCOLYTIC VIRUS 1

CAN-3110

2026

A single intratumoral injection of CAN-3110 produced deep and persistent T cell infiltration in recurrent GBM by locally expanding pre-existing tumor-infiltrating T cell clones; shorter GZMB+ CD8 T ce...

Cell

SUPPORTIVE CARE 1

EPCOG

2026

Monthly early palliative care did not significantly improve the primary FACT-Br Trial Outcome Index at 6 months, but produced consistent benefits in emotional well-being, palliative-care symptom burde...

Neuro-Oncology

TREATMENT 1

RTOG 1114

2026

Adding low-dose WBRT (23.4 Gy) to R-MPV-A chemoimmunotherapy substantially improved 2-year PFS (78.7% vs 54%, HR 0.47, P=0.007) and complete response rates without producing measurable excess neurocog...

Neuro-Oncology

BRAIN METASTASES 3

Does intraoperative radiotherapy delivered to the resection cavity provide effective local control and acceptable safety in patients with newly diagnosed brain metastases?

INTRAMET

2026
Journal of Neuro-Oncology

In patients with 5 to 20 brain metastases, does stereotactic radiation targeting individual tumors reduce symptom burden and interference with daily function compared with hippocampal-avoidance whole brain radiation?

HipSter

2026
JAMA

Does stereotactic radiation provide better patient-reported outcomes than hippocampal-avoidance whole brain radiation in patients with 5-20 brain metastases?

SRS vs HA-WBRT for Brain Metastases

2026
JAMA

THERAPEUTICS 2

Can a CDK4/6 inhibitor shrink or stabilize progressive meningiomas harboring NF2 or CDK pathway mutations?

Alliance A071401

2026
Nature Medicine

Does oncolytic herpes virus treatment reprogram the glioblastoma immune microenvironment to enable T cell-mediated tumor killing?

rQNestin GBM

2026

Oncolytic Virus for Recurrent Glioblastoma — Spatial Omics Analysis

Cell