Does stereotactic radiation provide better patient-reported outcomes than hippocampal-avoidance whole brain radiation in patients with 5-20 brain metastases?
Does intraoperative radiotherapy delivered to the resection cavity provide effective local control and acceptable safety in patients with newly diagnosed brain metastases?
INTRAMET
Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET)
Journal of Neuro-Oncology · 2026
Bottom Line: Low-energy X-ray IORT (30 Gy at the applicator surface) delivered to the resection cavity at the time of brain metastasis resection achieved a 94.3% local control rate at 1 and 2 years with no grade 4/5 IORT-related toxicities, suggesting it may be a feasible alternative to postoperative stereotactic radiosurgery in…