IIH Provoke
2026In a small (n=16) double-blind, placebo-controlled, two-way crossover provocation study, IV CGRP triggered typical IIH headache in 44% of women and was accompanied by elevations in 8 pro-nociceptive a...
Is IV fosphenytoin superior to placebo in reducing pain intensity at 120 minutes in patients with acute trigeminal neuralgia exacerbations?
NORO ET AL
IV Fosphenytoin for Acute Trigeminal Neuralgia: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Neurology · 2026
Bottom Line: In patients with acute trigeminal neuralgia exacerbations, IV fosphenytoin (18 mg/kg load, 7.5 mg/kg maintenance) provided rapid, clinically meaningful pain relief at 120 minutes compared with placebo, with mild and transient adverse events — supporting IFT as a viable short-term rescue/bridging therapy, though findings are preliminary given the small sample.