NeuroTrials Wiki - All Topics

A comprehensive evidence-based neurology knowledge base. Browse all available topics below.

← Back to Wiki

Ischemic Stroke

Acute Management

• History of tPA
• Expanding the Window
• Expanding Indications
• Minor Stroke
• Contraindications
• Complications
• Special Situations
• New Thrombolytics
• Adjuvants
• Post-Thrombolysis Care
• History of Thrombectomy
• Beyond 6h Window
• Distal Occlusions
• Large Core Infarcts
• Tandem Occlusions
• Post-Thrombectomy Care
• Vascular Imaging
• Echocardiogram
• Cardiac CT
• Cardiac Monitoring
• Laboratory Tests

Prevention

• Antiplatelet Therapy
• Anticoagulation
• Carotid Stenosis
• Dissection
• Intracranial Stenosis
• Atrial Fibrillation
• PFO Closure
• Lipid Management
• Hypertension
• Diabetes Management
• Lifestyle Modifications
• Perioperative Stroke
• Primary Prevention 2024 Guidelines

Other Stroke Etiologies

• Cerebral Venous Thrombosis
• Monogenic Stroke Syndromes
• Non-Atherosclerotic Arteriopathies
• Inflammatory Stroke Causes
• Infectious Vasculopathies
• Hematologic Stroke Causes

Rehabilitation

• Early Recovery & Rehab Principles
• Motor & Functional Recovery
• Spasticity Management
• Neuropsychiatric & Pain Syndromes
• Vagal Nerve Stimulation
• Transcranial Magnetic Stimulation
• Transcranial Direct Current Stimulation

Guidelines

• Acute Stroke Treatment 2026
• Dyslipidemia Management 2026
• Secondary Prevention 2021
• Primary Prevention 2024

Hemorrhagic Stroke

Intracerebral Hemorrhage

• Blood Pressure Management
• Hemostasis & Reversal
• Surgical Management
• Care Bundles & Neuro-ICU
• Antithrombotic Therapy
• Recurrence Prevention

Subarachnoid Hemorrhage

• Diagnosis & Initial Assessment
• Clipping vs. Coiling
• Vasospasm & DCI
• Neuro-ICU Complications

Subdural Hematoma

• Surgical Intervention
• MMA Embolization
• Conservative Management

Guidelines

• SAH Guidelines 2023
• ICH Guidelines 2022

Headache

Migraine

• Migraine Subtypes
• Chronic Migraine
• Headache Red Flags
• Emergency Department
• Acute Management at Home
• Status Migrainosus
• CGRP Monoclonal Antibodies
• Gepants for Prevention
• Sequencing CGRP Therapies
• Beta-Blockers
• Antiepileptics
• Antidepressants
• OnabotulinumtoxinA
• Neuromodulation Devices
• Acupuncture
• Nerve Blocks
• Menstrual Migraine
• Migraine in Pregnancy
• Pediatric Migraine
• Refractory Migraine

Tension-Type Headache

• Diagnosis & Clinical Picture
• Acute & Preventive Treatment

Trigeminal Autonomic Cephalalgias

• Acute Treatment
• Transitional Therapy
• Preventive Treatment
• Paroxysmal Hemicrania
• SUNCT & SUNA
• Hemicrania Continua

Secondary Headaches

• Medication Overuse Headache
• Post-Traumatic Headache
• New Daily Persistent Headache

CSF Dynamics

• SIH: Diagnosis & Imaging
• SIH: Treatment of Spinal CSF Leaks
• IIH: Diagnosis & Clinical Features
• IIH: Treatment & Monitoring
• Persistent Headache After CSF Pressure Normalization

Guidelines

• Acute Migraine in ED

Epilepsy

Classification & Diagnosis

• Seizure Types & ILAE Classification
• Semiology & Seizure Localization
• First Seizure Evaluation
• Epilepsy Imitators & Differential Diagnosis

Adult Epilepsy Syndromes

• Temporal Lobe Epilepsy
• Frontal & Extratemporal Epilepsies
• Juvenile Myoclonic Epilepsy
• Other Idiopathic Generalized Epilepsies
• Reflex Epilepsies
• Progressive Myoclonic Epilepsies

Childhood Epilepsy Syndromes

• Febrile Seizures & Self-Limited Focal Epilepsies
• Childhood & Juvenile Absence Epilepsy
• Infantile Epileptic Spasms (West)
• Lennox-Gastaut Syndrome
• Dravet Syndrome & SCN1A Spectrum
• Tuberous Sclerosis & mTOR Pathway
• CSWS, Landau-Kleffner & Sleep-Related Epilepsies
• Neonatal & Early Infantile Epileptic Encephalopathies
• Doose, GEFS+ & Rasmussen Syndrome

Status Epilepticus

• Convulsive Status Epilepticus
• Nonconvulsive Status Epilepticus
• Refractory & Super-Refractory SE

Autoimmune & Acute Seizures

• Autoimmune Epilepsy
• NORSE & FIRES
• Acute Symptomatic Seizures
• Seizure Clusters & Rescue Therapy

Antiseizure Medications

• ASM Selection & Treatment Initiation
• Broad-Spectrum ASMs
• Focal Epilepsy ASMs
• Cenobamate & Newer ASMs
• Drug Interactions & Pharmacokinetics
• ASM Withdrawal & Discontinuation

Surgery & Neuromodulation

• Presurgical Evaluation
• Resective & Disconnective Surgery
• Vagus Nerve Stimulation
• RNS & Thalamic DBS
• Laser Interstitial Thermal Therapy

EEG & Neuroimaging

• Routine EEG Interpretation
• Epileptiform Patterns & Normal Variants
• Continuous EEG & ICU Monitoring
• Long-Term Monitoring & Ambulatory EEG
• MRI in Epilepsy: Protocols & Lesions
• Advanced Imaging: PET, SPECT & MEG

Special Populations

• Women & Epilepsy: Pregnancy & Contraception
• Epilepsy in the Elderly
• Epilepsy & Psychiatric Comorbidities
• Cognitive Effects of Epilepsy & ASMs

Safety & Quality of Life

• SUDEP: Risk Factors & Prevention
• Driving, Employment & Legal Issues
• Transition of Care & Self-Management
• Precision Medicine & Gene Therapy

Guidelines

• SE Treatment (AES 2016)
• SUDEP (AAN 2017)
• fMRI Presurgical (AAN 2017)
• New AED Efficacy (AAN 2018)
• First Seizure (AAN 2015)
• Genetic Testing (AES 2022)
• ASM & Pregnancy (AAN 2024)
• Functional Seizures (AAN 2025)

Neuroimmunology

Multiple Sclerosis

• Epidemiology & Pathophysiology
• Diagnosis & 2024 McDonald Criteria
• Mimickers & Differential Diagnosis
• RIS & Clinically Isolated Syndrome
• Disease-Modifying Therapies
• Relapse Management & Symptom Treatment
• Progressive Multiple Sclerosis

Demyelinating Disorders

• NMOSD: Diagnosis & Clinical Features
• NMOSD: Treatment & Relapse Prevention
• MOGAD: Diagnosis & Clinical Features
• MOGAD: Treatment & Outcomes

Autoimmune Encephalitis

• Overview & Diagnostic Approach
• Anti-NMDA Receptor Encephalitis
• LGI1 & CASPR2 Encephalitis
• Other Autoimmune Encephalitides
• Paraneoplastic Neurologic Disorders

Neurorheumatologic Disorders

• Neurosarcoidosis & CNS Vasculitis
• Neuro-Lupus, Neuro-Sjögren & Neuro-Behçet
• Other Rheumatologic Neurologic Manifestations

Pediatric Neuroimmunology

• Pediatric Autoimmune Encephalitis & Demyelination
• Pediatric MS & Acquired Demyelinating Disorders

Therapeutics

• Acute Immunotherapy
• Chronic Immunosuppression & Biologic Therapies
• MS Disease-Modifying Therapies
• Emerging Therapies

Movement Disorders

Parkinson's Disease

• Diagnostic Criteria & Biological Staging
• Motor and Non-motor Symptoms
• Differential Diagnosis of Parkinsonism
• Motor Symptom Treatment
• Non-Motor Symptom Treatment
• Motor Complications
• Deep Brain Stimulation
• Infusion & Device-Based Therapies
• Focused Ultrasound
• α-Synuclein & Emerging Targets

Atypical Parkinsonism

• Multiple System Atrophy
• Progressive Supranuclear Palsy
• Dementia with Lewy Bodies
• Corticobasal Degeneration

Essential Tremor

• Classification & Diagnosis
• Medical Management
• Surgical & FUS Therapies

Dystonia

• Classification & Diagnosis
• Treatment

Huntington's Disease

• Diagnosis & Clinical Symptoms
• Treatment
• Disease-Modifying Trials

Ataxia & Cerebellar Disorders

• Spinocerebellar Ataxias
• Friedreich Ataxia
• CANVAS & RFC1 Spectrum
• Episodic Ataxias
• Acquired & Immune-Mediated Ataxias

Tardive Syndromes

• Tardive Dyskinesia
• Tardive Dystonia

Autoimmune Movement Disorders

• Stiff Person Syndrome
• Other Autoimmune Movement Disorders

Other Movement Disorders

• Chorea, Myoclonus & Tics
• Tics & Tourette Syndrome
• Paroxysmal Dyskinesias
• Drug-Induced Movement Disorders
• Functional Movement Disorders
• Wilson Disease
• Restless Legs Syndrome

Guidelines & EBM Reviews

• Parkinson Disease Motor Symptoms (2018)
• Parkinson Disease Motor Fluctuations Update (2025)
• Parkinson Disease Non-Motor Symptoms (2011)
• Essential Tremor (2019)
• MDS Diagnostic Criteria: PD, MSA & PSP
• AAN Essential Tremor Treatment (2011, reaffirmed 2025)
• European HD Network: HD Treatment (2019)
• German Neurology Society: PD Pharmacotherapy (2024)
• AASM: RLS/PLMD Treatment (2025)

NeuroMuscular

Clinical Approach

• Pattern Recognition & Localization
• Diagnostic Algorithm & Red Flags

Diagnostic Tools

• NCS & EMG Interpretation
• Neuromuscular Junction Testing
• Autonomic Testing
• Genetic Testing & Diagnostic Pitfalls

Peripheral Neuropathies

• Length-Dependent Polyneuropathy
• CIDP Spectrum
• Vasculitic Neuropathy
• Hereditary Neuropathies (CMT)
• Small Fiber Neuropathy
• Toxic & Metabolic Neuropathies

Motor Neuron Diseases

• Amyotrophic Lateral Sclerosis
• Spinal Muscular Atrophy
• Other Motor Neuron Diseases

NMJ Disorders

• Myasthenia Gravis
• Lambert-Eaton Myasthenic Syndrome
• Other NMJ Disorders
• Myasthenic Crisis Management

Inflammatory Myopathies

• Dermatomyositis
• Polymyositis & Immune-Mediated Necrotizing Myopathy
• Inclusion Body Myositis
• Muscle Testing, Biopsy & Antibodies

Genetic Myopathies

• Dystrophinopathies (DMD & BMD)
• Limb-Girdle Muscular Dystrophies
• Myotonic Dystrophy
• Channelopathies & Periodic Paralysis
• Congenital Myopathies

Metabolic Myopathies

• Glycogen Storage Myopathies
• Lipid Myopathies & Fatty Acid Oxidation Defects
• Mitochondrial Myopathies
• Exercise Intolerance & Diagnostic Approach

NM Emergencies

• Guillain-Barré Syndrome
• Acute Myopathies & Rhabdomyolysis
• Critical Illness Neuromyopathy
• Toxin-Related Paralysis & ICU Management

Advanced Therapies

• Pediatric Neuromuscular Disorders
• Pregnancy & Neuromuscular Disease
• Paraneoplastic Neuromuscular Syndromes
• Gene Therapy, RNA Therapeutics & Future Directions

Dementia

Alzheimer Disease

• Epidemiology & Risk Factors
• Clinical Presentation & Cognitive Profile
• Diagnostic Criteria & Biological Staging
• Atypical Presentations of AD
• Cholinesterase Inhibitors & Memantine
• Anti-Amyloid Immunotherapy
• Emerging & Pipeline Therapies

Frontotemporal Dementia

• Behavioral Variant FTD
• Primary Progressive Aphasia
• FTD-Motor Neuron Disease Spectrum
• Symptomatic Management of FTD

Lewy Body Dementia

• Clinical Features & Diagnostic Criteria
• Biomarkers & Differential Diagnosis
• Symptomatic Management of LBD

Vascular Cognitive Impairment

• Subtypes & Risk Factors
• Diagnosis & Neuroimaging
• Prevention & Treatment

Other Dementias & Neuropathology

• LATE & Hippocampal Sclerosis
• Primary Age-Related Tauopathy
• Genetics of Neurodegenerative Dementias
• Neuropathology of Common Dementias

Biomarkers & Neuroimaging

• Blood-Based Biomarkers
• CSF Biomarkers & ATN Framework
• Structural & Functional Neuroimaging
• Amyloid & Tau PET Imaging
• ARIA Monitoring

Neuropsychiatric Symptoms

• Clinical Assessment & Localization
• Pharmacologic Management
• Non-Pharmacologic Approaches

Care & Practice

• Care Partner Burden & Support
• Support Services & Resources
• Implementing New Care Models

Others

Neuro-Ophthalmology

• Optic Neuritis
• Ischemic Optic Neuropathy
• Papilledema
• Third Nerve Palsy
• Fourth & Sixth Nerve Palsies
• INO & Supranuclear Gaze Palsies
• Pupil Disorders
• Nystagmus Classification & Localization
• Visual Field Localization

Neuro-Oncology

• Glioma Classification & Molecular Markers
• Glioma Treatment
• Meningiomas
• Pituitary Tumors
• Brain Metastases
• CNS Lymphoma
• Leptomeningeal Disease
• Paraneoplastic Neurologic Syndromes
• Neurotoxicity of Cancer Therapies

Neuroinfectious Disease

• Bacterial Meningitis
• Brain Abscess & Empyema
• Neurosyphilis
• Tuberculous Meningitis
• HSV Encephalitis
• HIV Neurology
• Progressive Multifocal Leukoencephalopathy
• Fungal & Parasitic CNS Infections
• Prion Diseases

Neuro-Otology

• BPPV
• Vestibular Neuritis
• Meniere Disease
• Superior Canal Dehiscence
• Vestibular Migraine
• Central Causes of Vertigo
• Bedside Vestibular Examination
• Vestibular Function Testing

Autonomic Disorders

• Postural Tachycardia Syndrome
• Neurogenic Orthostatic Hypotension
• Pure Autonomic Failure
• Autoimmune Autonomic Ganglionopathy
• Autonomic Testing

Neurorehabilitation

• Motor Recovery & Neuroplasticity
• Aphasia Rehabilitation
• Post-Stroke Cognitive Rehabilitation
• Spasticity Assessment & Management
• Botulinum Toxin for Spasticity
• Functional Outcomes & Scales

---

Total topics: 352 | View Sitemap